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In: Application of Peptide-Based Prodrug Chemistry in Drug Development
The principal regulator of glutamine utilization is the transcription factor c-myc , which is often upregulated in proliferating cells [17,18]
Methylcobalamin, a form of vitamin B12, is utilized in the treatment of various conditions such as neuropathy, anemia, B12 deficiency, megaloblastic anemia, and Leber's disease
Interestingly, the administration of SP, L-car, and their combination was able to reverse the changes in hormonal levels as presented in the DOX + SP, DOX + L-car, and DOX+(SP + L-car) groups, especially the DOX+(SP + L-car), unlike the DOX group, reflecting their protective role against ovarian toxicity induced by DOX
